ETHICS REQUIREMENTS
will ensure compliance with the ‘ethics requirements’.
WP1
WP2
PHENOTYPING NEUROPATHIC AND CANCER PAIN PATIENTS
will perform a thorough characterisation of neuropathy and cancer pain patients using standardised set of clinical, neurophysiologic and neuropathologic tools.
WP2
WP3
ELECTROPHYSIOLOGICAL MEASURES OF PAIN MAGNITUDE IN THE PERIPHERAL NERVOUS SYSTEM
aims to: identify and characterise patients with peripheral neuropathic pain suitable for microneurographic recordings; perform microneurographic recording of spontaneous discharge of different classes of nociceptors and quantify their excitability in pain patients and healthy subjects; establish a spontaneous pain model by combining nociceptor sensitisation and inflammation; compare microneurography results to classic readouts (Quantitative Sensory Testing, Nerve Conduction Studies, Pain-related Evoked Potentials).
WP4
GENETICS OF PAIN
will investigate the genetic bases of neuropathic pain, cancer pain and responsiveness to analgesics.
WP4
WP5
IN VITRO FUNCTIONAL ANALYSES OF PAIN CAUSATIVE GENE MUTATIONS
aims to in vitro analyse the pathogenic potential of mutations in sodium channel genes identified in patients with neuropathic pain through clinical and genetic assessment; to use functional proteomics for identification and characterization of peripheral sodium channel signalling complexes.
WP6
IONFLUX HIGH-THROUGHPUT SCREENING OF ANALGESIC COMPOUNDS
aims to perform in vitro high-throughput screening of conventional and proprietary analgesic compounds targeting ion channels
WP6
WP7
CREATION AND CHARACTERISATION OF PAIN-RELATED SODIUM CHANNEL CRISPR-CAS MOUSE MODELS
aims to create and characterise the first transgenic mouse models of sodium-channel-related neuropathic pain.
WP8
CREATION AND ASSESSMENT OF NEUROPATHIC CHRONIC ITCH MOUSE MODEL
aims to develop and evaluate in in vitro and in vivo models of chronic itch and to validate treatment in mouse models
WP8
WP9
TRAINING ACTIVITIES
aims at providing a substrate to training activity through the different sectors and research units.
WP10
DISSEMINATION, COMMUNICATION AND PUBLIC ENGAGEMENT ACTIVITIES
aims to spread PAIN-Net to the largest audience in line with Open Innovation, Open Science, Open to the World strategy; carry out information and awareness initiatives; to promote communication towards the general public and to increase awareness of science.
WP10
WP11
EXPLOITATION AND INNOVATION
aims to identify exploitable results and plan an exploitation strategy; to contribute to the European Innovation Union.
WP12
PROJECT MANAGEMENT
will link together the project components, to maintain communication with the EC, to establish and adopt common operational and research and training procedures, to ensure consistent technical reporting to the REA, to monitor compliance of all beneficiaries with their obligations, to ensure a correct and timely financial management and reporting, to administer the EC contribution, to ensure respect of ethical issues and attention paid to gender issues.
WP12