will ensure compliance with the ‘ethics requirements’.
will perform a thorough characterisation of neuropathy and cancer pain patients using standardised set of clinical, neurophysiologic and neuropathologic tools.
aims to: identify and characterise patients with peripheral neuropathic pain suitable for microneurographic recordings; perform microneurographic recording of spontaneous discharge of different classes of nociceptors and quantify their excitability in pain patients and healthy subjects; establish a spontaneous pain model by combining nociceptor sensitisation and inflammation; compare microneurography results to classic readouts (Quantitative Sensory Testing, Nerve Conduction Studies, Pain-related Evoked Potentials).
will investigate the genetic bases of neuropathic pain, cancer pain and responsiveness to analgesics.
aims to in vitro analyse the pathogenic potential of mutations in sodium channel genes identified in patients with neuropathic pain through clinical and genetic assessment; to use functional proteomics for identification and characterization of peripheral sodium channel signalling complexes.
aims to perform in vitro high-throughput screening of conventional and proprietary analgesic compounds targeting ion channels
aims to create and characterise the first transgenic mouse models of sodium-channel-related neuropathic pain.
aims to develop and evaluate in in vitro and in vivo models of chronic itch and to validate treatment in mouse models
aims at providing a substrate to training activity through the different sectors and research units.
aims to spread PAIN-Net to the largest audience in line with Open Innovation, Open Science, Open to the World strategy; carry out information and awareness initiatives; to promote communication towards the general public and to increase awareness of science.
aims to identify exploitable results and plan an exploitation strategy; to contribute to the European Innovation Union.
will link together the project components, to maintain communication with the EC, to establish and adopt common operational and research and training procedures, to ensure consistent technical reporting to the REA, to monitor compliance of all beneficiaries with their obligations, to ensure a correct and timely financial management and reporting, to administer the EC contribution, to ensure respect of ethical issues and attention paid to gender issues.